In Haliotis, NO means YES

In Haliotis, NO means YES

Settlement and metamorphosis of marine invertebrate larvae is an ecological process of profound importance to the structure of benthic marine communities. Yet, metamorphosis is also a developmental process and our understanding of the mechanisms that regulate it remains relatively poor. Over the last 15 years, a nitric oxide (NO) based signaling system has emerged as the most phylogenetically w...

No NO means yes to sickle red cell adhesion.

In fact, patients with these conditions are particularly prone to developing refractoriness to platelet transfusions, and treatment of bleeding in this situation represents a major clinical problem. The data presented by Colucci et al provide a rationale for hoping that DDAVP can be effective in these emergencies as well as in preparation of patients for surgery or invasive procedures. Much wor...

Endothelial Insulin and IGF-1 Receptors: When Yes Means NO

Cardiovascular (CV) disease is the leading cause of morbidity and mortality and a major driver of health care costs in patients with type 2 diabetes. Observational studies suggest that insulin resistance and hyperglycemia independently predict atherosclerosis (1,2). However, recent clinical trials have been disappointing in that intensive glycemic control does not reduce the risk of CV events i...

Genetically Modified Food: Yes or No?

radical iort, yes or no?

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